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Barbiturates lower serum bilirubin concentrations Per neonates and patients with congenital nonhemolytic unconjugated hyperbilirubinemia, presumably by induction of glucuronyl transferase, the enzyme that conjugates bilirubin.

Barbiturates do not impair normal hepatic function, but have been shown to induce liver microsomal enzymes, thus increasing and/or altering the metabolism of barbiturates and other drugs. (See “DRUG INTERACTIONS” section).

Do not use pentobarbital Per patients with hypersensitivity to barbiturates or any of the components in pentobarbital.

Hypnotic doses of these barbiturates do not appear to significantly impair uterine activity during labor. Full anesthetic doses of barbiturates decrease the force and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates to the mother during labor may result Per respiratory depression Con the newborn.

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 At low doses, approved indications of pentobarbital include short-term sedatives to treat insomnia and as a pre-anesthetic agent for surgery Per the operating room.[1] At elevated doses, pentobarbital functions as an anticonvulsant for emergent seizure control and for inducing medically induced comas.

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This is not a complete list of all side effects or adverse reactions that may get more info occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.

Additionally, it is used for the short-term treatment of insomnia and as a pre-anesthetic Sopra the operating room. Pentobarbital has also been used to induce coma Per mezzo di individuals with cerebral ischemia and to lower intracranial pressure in situations like Reye’s syndrome and traumatic brain injury.

Nei more info Paesi Bassi il pentobarbital né ha alcun uso terapeutico ed è utilizzato derelitto Attraverso questo meta.

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Documented evidence of withdrawal exists in infants born to mothers who took barbiturates during pregnancy. Newborns should be closely monitored for seizures and hyperirritability, which may indicate a need for withdrawal treatment. Symptoms can be delayed for up to 2 weeks and require prompt treatment if indicated.[25]